Publications

Machedo P, Allison L, Penn M, Fleck R*, Devoy A* (2024) AI-driven segmentation and volume analysis of SBF-SEM images from complex biological samples (In process, submission July 2024)

Milioto C, Carcolé M, Giblin A, Coneys R, Attrebi O, Ahmed M, Harris SS, Nirujogi RS, Biggs D, Salomonsson S, Zanovello M , De Oliveira P, Katona E, Glaria I, Mikheenko A, Geary B, Udine E, Vaizoglu D, Rademakers R, van Blitterswijk M, Devoy A, Hong S, Partridge L, Fratta P, Alessi DR, Davies B, Busche M, Greensmith L, Fisher EMC, Isaacs AMet al. (2024) PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nat Neurosci. Feb 29. Epub ahead of print. PMID: 38424324

Devoy A, Price G, De Giorgio F, Bunton-Stasyshn R, Thopson D, Gasco S, Allan A, Codner GF, Nair RR, Tibbit C, McLeod R, Ali Z, Noda J, Marrero-Gagliardi A, Brito-Armas JM, Ozturk MM, Simon M, O’Neill E, Bryce-Smith S, Harrison J, Atkins G, Corrochano S, Stewart M, Teboul L, Acevedo-Arozena A, Fisher EMC, Cunningham TJet al. (2021) Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience 24(12):103463 PMID: 34988393

Birsa N, Ule AM, Garone MG, Tsang B, Mattedi F, Chong PA, Humphrey J, Jarvis S, Pisiren M, Wilkins OG, Nosella ML, Devoy A, Bodo C, de la Fuente RF, Fisher EMC, Rosa A, Viero G, Forman-Kay JD, Schiavo G, Fratta Pet al. (2021) FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation. Sci Adv. (30):eabf8660 PMID: 34290090

Reber S, Jutzi D, Lindsay H, Devoy A, Mechtersheimer J, Domanski M, Mühlemann O, Barabino S.M.L, Ruepp MDet al. (2021) The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation. Nucleic Acids Res. 49(13):7713-7731. PMID: 34233002

Jutzi D, Campagne S, Schmidt R, Reber S, Mechtersheimer J, Gypas F, Schweingruber C, Colombo M, von Schroetter C, Loughlin F, Devoy A, Hedlund E, Zavolan M, Allain FHT, Ruepp MDet al. (2020) Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced Amyotrophic Lateral Sclerosis. Nat Comms. 11(1):6341 PMID: 33311468

Humphrey J, Birsa N, Milioto C, Robaldo D, Eberle AB, Kräuchi R, Bentham M, Ule AM, Jarvis S, Bodo C, Garone MG, Devoy A, Rosa A, Bozzoni I, Fisher EMC, MD Ruepp, Mühlemann O, Schiavo G, Isaacs AM, Plagnol V, Fratta Pet al. (2020) FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Nucleic Acids Res. 48(12):6889-6905 PMID: 32479602

Sleigh J, Tosolini AP, Gordon D, Devoy A, Fratta P, Fisher EMC, Talbot K, Schiavo Get al. (2020) Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes. Cell Rep. 30(11):3655-3662.e2 PMID: 32187538

Devoy A*, Kalmar B, Stewart M, Park H, Burke B, Noy S, Redhead Y, Humphrey J, Lo K, Jaeger J, Mejia Maza A, Bertolin C, Soraru G, Plagnol V, Greensmith L, Acevedo Arozena A, Isaacs A, Davies B, Fratta P, Fisher EMC*et al. (2017) Humanised mutant FUS drives progressive motor neuron degeneration without aggregation in ‘FUSDelta14’ knockin mice. Brain, 140(11):2797-2805 (*corresponding author) PMID: 29053787

McKinnon C, Goold R, Andre R, Devoy A, Ortega Z, Moonga J, Linehan JM, Brandner S, Lucas JJ, Collinge J, Tabrizi SJet al. (2016) Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta Neuropathol. 131(3):411-25 PMID:26646779

Chassefeyre R, Martínez-Hernández J, Bertaso F, Bouquier N, Blot B, Laporte M, Fraboulet S, Couté Y, Devoy A, Isaacs A, Pernet-Gallay K, Sadoul R, Fagni L, Goldberg, Y.et al. (2015) Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci 35:3155-73 PMID: 25698751

Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IO, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EM, Partridge L, Isaacs AM.et al. (2014) C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science. Sep 5; 345:1192-4. PMID: 25103406

Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, Mok K, Collins T, Shoaii M, Nanji T, Wray S, Adamson G, Pittman A, Renton AE, Traynor BJ, Sweeney MG, Revesz T, Houlden H, Mead S, Isaacs AM, Fisher EMet al. (2014) Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion. Neurobiol Aging. Aug 1. pii: S0197-4580(14)00506-5 PMID: 25179228

Fratta P, Charnock J, Collins T, Devoy A, Howard R, Malaspina A, Orrell R, Sidle K, Clarke J, Shoai M, Lu CH, Hardy J, Plagnol V, Fisher EM.et al. (2013) Profilin1 E117G is a moderate risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. Dec 5 PMID:24309268

Fratta P, Collins, T, Pemble, S, Nethisinghe, S, Devoy, A., Giunti, P., Sweeney, M.G., Hanna, M.G., Fisher, E.M.C.,et al. (2013) Sequencing analysis of the SBMA CAG expansion reveals absence of repeat interruptions. Neurobiology of Ageing 35: 433.e1-3 PMID:24041967

Devoy, A, Bunton-Stasyshyn, RKA, Tybulewicz, VLJ, Smith, AJH, Fisher, E.M.C.et al. (2012) Genomically humanized mice: technologies and promise. Nature Rev Genet 13: 14-20 PMID:22179716

Devoy, A, Fisher, EMC (2009) Commentary for Alzforum on Perlson et al A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J. Neurosci 29: 9903-9917

Bedford, L., Hay, D., Devoy, A., Paine, S., Powe, D.G., Seth, R., Gray, T., Topham, I., Fone, K., Rezvani, N., Mee, M., Soane, T., Layfield, R., Sheppard, P.W., Ebendal, T., Usoskin, D., Lowe, J., Mayer, R.J.et al. (2008) Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci. 28 8189-98. PMID:18701681

De Vita S, Devoy A, Groet J, Kruslin B, Kuzmic-Prusac I, Nizetic D.et al. (2008) Megakaryocyte hyperproliferation without GATA1 mutation in foetal liver of a case of Down syndrome with hydrops foetalis. Br J Haematol. Oct;143(2) :300-3. PMID: 18699852

Devoy A, Soane T, Welchman R, Mayer RJ. (2005) The Ubiquitin-Proteasome System and Cancer. Essays Biochem. 41:187-203. PMID:16250906

Devoy, AF. Dyet KH, Martin DR. (2005) Stability of PorA during a meningococcal disease epidemic. J Clin Microbiol. 43(2):832-7. PMID: 15695688

Dyet K, Devoy A, McDowell R, Martin D. (2005) New Zealand's epidemic of meningococcal disease described using molecular analysis: implications for vaccine delivery. Vaccine. 18;23(17-18):2228-30. PMID: 15755601